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Year : 2020  |  Volume : 4  |  Issue : 3  |  Page : 421-426

Serum Beclin 1 in HCC and correlation with MDA as an oxidant

1 Department of Internal Medicine, Al Azhar University, Cairo, Egypt
2 Department of Department of Medical Biochemistry, Medical Division National Research Center, Cairo, Egypt
3 Department of Diagnostic Radiology, Faculty of Medicine for Girls, Al Azhar University, Cairo, Egypt

Correspondence Address:
MBBCH Zeinab A Mohammed
Department of Internal Medicine, Al Azhar University, Faculty of Medicine (For Girls), AL-Azhar University, Al_Mansoura, Al Dakhlia, 35511
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/sjamf.sjamf_63_20

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Background Hepatocellular carcinoma (HCC) is the second most lethal cancer worldwide with persistently increasing mortality in Europe, North/South America, and Africa, in contrast to the decreasing trend in East Asia. Cirrhosis was estimated to cause more than 1.2 million deaths (2% of global deaths) in 2013, an increase of 47% since 1990. Aim The aim was to assess serum Beclin 1 as a biomarker in HCC regarding its role in pathogenesis and its correlation with serum malondialdehyde (MDA) as an oxidant. Patients and methods This is a case–control study conducted on 60 participants who were divided into two groups: group 1 included 30 patients with HCC, comprising 26 males and four females, with ages ranging from 55 to 75 years. Group II included 30 healthy participants as a control group, comprising 21 males and nine females, with ages ranging from 25 to 42 years. Routine laboratory investigations were done, and serum Beclin 1 and serum MDA were measured in both groups. Abdominal ultrasonography and triphasic computed tomography were done for the patient group. All patients were recruited from Internal Medicine Department (Al-Mansoura University Hospital) after obtaining oral consent to be participated in the study. Results There was a highly significant decrease in serum Beclin 1 levels (<0.001) in patients with HCC when compared with the control group. The significant association between Beclin 1 and HCC suggests that low Beclin 1 levels may play an important role in the development of HCC. Moreover, there was a statistically significant increased serum MDA level (>0.001) in patients with HCC as compared with control group. There was a positive correlation between Beclin 1 and BMI in the patient group (r=0.42 and P=0.02), a negative correlation between MDA and red blood cells in the patient group (r=−0.40 and P=0.03), and a positive correlation between MDA and aspartate transaminase in the patient group (r=0.41 and P=0.02). Conclusion Findings of our study have demonstrated that serum Beclin 1 and MDA levels could be used as possible predictors of pathogenesis of HCC.

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