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Year : 2020  |  Volume : 4  |  Issue : 3  |  Page : 358-364

Effect of high serum uric acid level on systemic lupus erythematosus manifestations

Department of Internal Medicine, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt

Correspondence Address:
MBBC Amany F Ali
Department of Internal Medicine, Faculty of Medicine for Girls, Al-Azhar University, Kafr El Shiekh, 33713
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/sjamf.sjamf_36_20

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Background Systemic lupus erythematosus (SLE) is a chronic, progressive, autoimmune disorder that affects multiple organ systems, with a broad range of clinical and laboratory manifestations. Considering the role of uric acid (UA) as a pro-inflammatory compound in SLE, serum levels of UA and its relation to severity and activity of the disease were assessed in patients with SLE. Objectives To evaluate the relation between high serum UA and SLE manifestations and correlate it with the disease activity. Patients and methods This study was conducted on 40 patients with SLE fulfilling the 2012 SLICC criteria for SLE classification and 20 sex-matched and age-matched apparently healthy participants as control group. All patients and controls were assessed by full clinical examination and laboratory investigations including serum urea and creatinine, serum lipids, 24-h urinary protein, antinuclear antibody, anti-double-stranded DNA, C3, C4, and serum UA. All patients were assessed for SLE disease activity by the systemic lupus erythematosus disease activity index. Results Serum UA was significantly higher in patients with SLE compared with the control group (P<0.001), and there was a significant increase of mean UA level in patients with active SLE (group Ia) compared with patients with inactive SLE (group Ib) (P<0.01). There were significant positive correlations between UA and protein in urine, pulmonary artery pressure, and disease activity in patients with SLE (group I) (r=0.362, 0.372, and 0.650, respectively; P<0.05). Conclusion Serum UA was higher in patients with SLE than control and correlated with disease activity, suggesting that it might play a role in SLE pathogenesis and can be used as a marker for SLE activity.

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