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ORIGINAL ARTICLE
Year : 2020  |  Volume : 4  |  Issue : 2  |  Page : 225-230

Association between hepatocellular carcinoma and type 2 diabetes in a sample of Egyptian patients


1 Department of Endocrinology and Metabolism, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt
2 Department of Diagnostic Radiology, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt

Correspondence Address:
Mervat E El-Wakeel
Assistant Professor of Endocrinology and Metabolism, Faculty of Medicine for Girls, Al-Azhar University, Piece 377, Area D, Street 9, Mokattam, Cairo
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/sjamf.sjamf_31_20

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Background Studies have reported association between type 2 diabetes mellitus (T2DM) and hepatocellular carcinoma (HCC). T2DM may cause nonalcoholic fatty liver disease-related HCC, suggesting a role of T2DM in hepatocarcinogenesis. Aim The aim was to study the association between HCC and some metabolic factors including insulin resistance and BMI in a sample of Egyptian patients with T2DM. Patients and methods The present work is a case–control study, conducted on 50 patients recently diagnosed as having HCC, and 30 participants as control. Patients and control were classified into diabetic and nondiabetic subgroups. Patients with other primary malignancies, organ failure, ascites, and autoimmune hepatitis were excluded. Results The study revealed that weight, BMI, waist circumference, fasting blood sugar, C peptide, homeostasis model assessment-insulin resistance, and glycosylated hemoglobin (HbA1c) were significantly higher in patients than control, and in diabetic and nondiabetic patients, than their controls. DM percent and duration were significantly higher in patients than control. In all patients, diabetic and nondiabetic, homeostasis model assessment-insulin resistance was significantly positively correlated with weight, BMI, waist circumference, fasting blood sugar, C peptide, and HbA1c. In diabetic patients, tumor size did not show significant correlation with the studied metabolic factors. Conclusion The most predictive factors in diabetic patients with HCC were C peptide, BMI, and HbA1c %.


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