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ORIGINAL ARTICLE
Year : 2020  |  Volume : 4  |  Issue : 2  |  Page : 203-209

The effect of nitric oxide to improve the ovulation and pregnancy rates in women with polycystic ovary syndrome treated with clomiphene citrate


1 BSc in 2011, in Medicine and General Surgery, Egypt
2 Department of Obstetrics and Gynecology, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt

Correspondence Address:
Mai M Farrag
Department of Obstetrics and Gynecology, Faculty of Medicine for Girls, Al-Azhar University, Cairo
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/sjamf.sjamf_22_20

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Background Polycystic ovary syndrome (PCOS), or also called anovulation, hyperandrogenic Stein–Leventhal syndrome, is one of the most common endocrinal disorders affecting ∼5–15% of women in the reproductive age. Aim The aim was to monitor the effect of nitric oxide (NO) on patients with PCOS treated with clomiphen citrate (CC) and to find out the effect on pregnancy and ovulation rates. Patients and methods The study was done on 90 patients divided into three groups: group A included 30 patients treated with CC only, group B included 30 patients treated with CC+10 mg NO, and group C included 30 patients treated with CC+20 mg NO. Results The ovulation and pregnancy rates increased significantly in patients treated with CC+NO compared with patients treated with CC alone. Conclusion The role of NO in induction of ovulation with CC in cases with PCOS increased the ovulation and pregnancy rates as a result of enhancement of follicular maturation and endometrial thickness and improvement of cervical mucus scoring.


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