• Users Online: 269
  • Print this page
  • Email this page
Year : 2020  |  Volume : 4  |  Issue : 2  |  Page : 196-202

Comparison between the efficacy of injection vs topical platelet-rich plasma as an adjuvant treatment of chronic venous ulcers

1 Department of Dermatology and Venereology, Faculty of Medicine (for Girls), Al-Azhar University, Cairo, Egypt
2 Department of Vascular Surgery, Faculty of Medicine (for Girls), Al-Azhar University, Cairo, Egypt

Correspondence Address:
MD Maisa A Abdel Wahab
Cairo, 11828
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/sjamf.sjamf_107_19

Get Permissions

Background Chronic venous ulcers are the most common type of leg ulcers and have a major influence on the quality of life and work productivity. Chronic nonhealing ulcers lack the needed growth factors and do not heal later. The use of platelet-rich plasma (PRP) is based on the fact that platelets contain many growth factors that have a well-known role in the course of ulcer repair. Aim and objective The aim was to evaluate and compare the efficacy of autologous PRP injection or topical application in the treatment of chronic venous ulcers. Patients and methods This study was conducted from April 2016 to January 2017 on 30 patients with chronic venous ulcer, who were divided into two equal groups: group A was treated by PRP injections in perilesional tissue, and group B was managed by topical application of PRP on the surface of the ulcer. Thereafter, the ulcers of both groups were covered with Vaseline gauze and then covered by thin elastic sheet without compression for six sessions with a 1-week interval between sessions. Results The study showed marked improvement in patients treated with injection and topical application of PRP after six sessions, with no statistically significant difference between the two groups regarding pressure ulcer scale for healing (PUSH) tool. Moreover, there was no statistically significant difference in healing ratio between both the groups. Conclusion PRP shows promise as an effective treatment in chronic venous ulcers by different methods of application. It is a safe, simple, and inexpensive without any adverse events.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded44    
    Comments [Add]    

Recommend this journal