• Users Online: 615
  • Print this page
  • Email this page
ORIGINAL ARTICLE
Year : 2020  |  Volume : 4  |  Issue : 1  |  Page : 42-51

Serum and urinary neutrophil gelatinase-associated lipocalin in chronic liver disease patients and its value in detecting renal impairment


1 Department of Tropical Medicine, Faculty of Medicine, Al-Azhar University, Cairo, Egypt
2 Department of Clinical Pathology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt

Correspondence Address:
MD Eman Elsayed Elshemy
MD Degree Tropical Medicine, Assistant Professor of Tropical Medicine Faculty of Medicine for Girls, Al-Azhar University
Egypt
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/sjamf.sjamf_110_19

Get Permissions

Background Renal dysfunction is a common complication of liver cirrhosis. Renal dysfunction has a serious impact on the natural evolution of liver cirrhosis. Treatment and prognosis may be improved if an early diagnosis could be established and specific therapeutic interventions would be applied. Several new markers have become topics of research with studies mainly focused on cystatin c, kidney injury molecule-1, and neutrophil gelatinase-associated lipocalin (NGAL). Aim Evaluation of serum and urinary NGAL in chronic liver disease patients and its value in the detection of renal impairment. Patients and methods It was performed on 45 patients with chronic liver disease and they were classified into three groups: group I included 15 patients with compensated chronic liver disease. Group II included 15 patients with decompensated liver disease and normal kidney functions. Group III included 15 patients with decompensated liver disease and impaired kidney functions. Results There was highly significant increase in serum creatinine and urea level in group III in comparison to groups I and II and there was significant decrease in glomerular filtration rate in group II in comparison to group I and highly significant decrease in group III in comparison to groups I and II. There was significant decrease in serum Na in group II in comparison to group I and in group III in comparison to group II and highly significant decrease in group III in comparison to group I. Also, there was highly significant decrease in urinary Na in group II and group III in comparison to group I and significant decrease in group III in comparison to group II. As regard NGAL there was significant increase of serum and urinary NGAL in group III in comparison to group I and group II. Conclusion Serum and urine NGAL are excellent markers for early detection of renal impairment in patients with chronic liver disease.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed80    
    Printed4    
    Emailed0    
    PDF Downloaded18    
    Comments [Add]    

Recommend this journal