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ORIGINAL ARTICLE
Year : 2019  |  Volume : 3  |  Issue : 3  |  Page : 635-642

Effects of prophylactic dose of ondansetron on hemodynamics during spinal anesthesia in cesarean section


Department of Anesthesia, Intensive Care and Pain Management, Faculty of Medicine for Girls, Al Azhar University, Cairo, Egypt

Correspondence Address:
Al Zahraa A Abbas
Department of Anesthesia, Intensive Care and Pain Management, Faculty of Medicine for Girls, Al Azhar University, Cairo
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/sjamf.sjamf_75_19

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Objective This study evaluated the efficacy of ondansetron during spinal anesthesia for cesarean section in overcoming the associated bradycardia and hypotension as the primary outcome and nausea, vomiting, intraoperative blood loss, and vasopressor requirements as the secondary outcomes. Patients and methods A total of 60 parturient women aged 20–40 years, with American Society of Anesthesiologists status I and II, scheduled for elective cesarean section under spinal anesthesia were divided into two equal groups in a randomized-controlled fashion. Before induction of spinal anesthesia, group I (n=30) received intravenous ondansetron 4 mg and group II (n=30) received normal saline. Hemodynamic variables, such as heart rate (beat/min), systolic blood pressure, diastolic blood pressure, mean arterial blood pressure (mmHg), nausea, vomiting, intraoperative blood loss (ml), and vasopressor requirements (mg), were recorded for each parturient woman. Results Blood pressure and heart rate were significantly decreased in group II in comparison with group I. Parturient in group I had significantly less requirement for vasopressor and had significantly lower incidences of nausea and vomiting. Conclusion In parturient women undergoing elective cesarean section, intravenous 4-mg ondansetron significantly decreased the hypotension, bradycardia, and vasopressor doses used.


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