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ORIGINAL ARTICLE
Year : 2019  |  Volume : 3  |  Issue : 3  |  Page : 587-595

Evaluation of serum matrix metalloproteinase-9 as a potential biomarker for diagnosis of epilepsy in children


1 Department of Pediatric, Faculty of Medicine, Al Azhar University, Cairo, Egypt
2 Department of Pediatric, National Research Centre; Department of Theodor Bilharzi Research Institute, National Research Centre, Cairo, Egypt
3 Department of Medical Biochemistry, National Research Centre, Cairo, Egypt
4 Department of Pediatric, New Cairo Hospital, Ministry of Health, Cairo, Egypt

Correspondence Address:
Maha S Zein Elabdeen
Mina House Tower Nasr City Cair Cairo
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/sjamf.sjamf_57_19

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Introduction Epilepsy is a common serious neurological disorder. Medical histories and electroencephalogram are not always sufficient for epilepsy diagnosis; therefore, exploring the novel methods for the accurate diagnosis of epilepsy is of great importance. Matrix metalloproteinase (MMP) are vital drivers of synaptic remodeling in health and disease. It plays a well described role in neuroinflammation; it is suggested that at early stages of epileptogenesis, inhibition of MMP may help ameliorate cell death, aberrant network rewiring, and neuroinflammation and prevent development of epilepsy. Aim MMPs especially MMP-9 and MMP-2 are sensitive to seizures; thus, MMP-9 may be a potential biomarker for epilepsy diagnosis, we assessed MMP-9 levels in the context of its possible use as a biomarker of the activity and diagnosis of epilepsy and evaluation of the nutritional state by anthropometric measurement. Patients and methods Thirty epileptic patients aged from 4 to 17 years, selected randomly from the inpatient and outpatient neurological unit of pediatric department in Alzhraa University Hospital between 2018 and 2019 were subjected to: etailed medical history, general and neurological examination, routine laboratory studies, electroencephalogram, anthropometric measurement, and serum MMP-9 level measurement. Thirty age-matched and sex-matched healthy controls were selected and their serum MMP-9 and anthropometric measurements were obtained. Results Serum MMP-9 levels were statistically significantly high in patients with idiopathic epilepsy compared with the control group. Sensitivity of MMP-9 as biomarkers was 62.07% with 96.67% specificity. The cutoff point of MMP-9 more than 4. Conclusion MMP-9 levels increased in patients with epilepsy. This tool may be a helpful diagnostic biomarker for epilepsy with good sensitivity and specificity.


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